Your 2020 organizing committee is hard at work putting together a program that brings together the best researchers in metabolic signaling from across Canada and beyond in an interactive and friendly environment. We are committed to promoting diversity and inclusion at all levels of the conference. We are able to cover a broad range of topics by offering parallel platform talks in adjacent rooms. Special joint sessions related to emerging themes at the interface of metabolism, cell signalling, and disease will bring together the entire conference community. There is something for everybody at CSMB2020. Check this site regularly for updates on our invited speakers!
Markus Ralser, The Francis Crick Institute and University of Cambridge
Dr. Rasler is an expert in systems biology of metabolism. His research team uses the yeast model system to understand how individual metabolic pathways change and adapt as a collective in response to stress. His group uses a combination of techniques include mass spectrometry to investigate rapid perturbations to cell homeostasis. His work has implications for diverse diseases including cancer, diabetes and neurological disorders. In 2016, Dr. Ralser was awarded the Biochemical Society's Colworth Medal for his work in the area of cellular metabolism.
Keywords: Systems biology, metabolism, model systems, mass spectrometry
Kidney Signalling - Chair: Dr. Erin Mulvihill, Ottawa Heart Institute
Invited Speaker: Dr. Lisa Robinson, SickKids Toronto
Dr. Robinson is a clinician-scientist whose lab studies the molecular mechanisms and cues including endothelial-expressed chemokines and sex hormones that guide the migration and differentiation of a number of bone marrow derived cell types in a number of conditions including inflammation, bone formation and kidney disease. She utilizes a number of genetic and pharmacologic approaches at both the cellular and whole organism level. She also has an active clinical research program based on the improving the care of renal transplant recipients, patients with immune-mediated kidney disease and children with kidney disease.
Keywords: osteoclasts, sex hormones, kidney disease, leukocytes, inflammation
Bacterial and viral signalling - Chair: Dr. Salim Timo Islam, INRS
Invited Speaker: Dr. Yves Brun, Université de Montréal
Dr. Brun is a recent recruit from Indiana University at Bloomington under the Canada 150 Chairs Program. His lab studies diverse questions related to the life and times of bacteria with a focus on Caulobacter as a model system. His work in Montreal will continue his award-winning NIH-funded work begun at Indiana University. Join us in Welcoming Dr. Brun to Canada!
Key words: Caulobacter, peptidoglycan, morphogenesis, biofilms, bacterial ageing
PTMs & Proteins - Chair: Dr. Mike Downey, uOttawa
Invited Speaker: Dr. Claire Eyers, University of Liverpool
Dr. Claire Eyers is a full professor at the University of Liverpool, UK. Her group focuses on the development of new mass spectrometry approaches to study non-canonical signaling pathways and protein-protein interactions. Some of her recent define a wide scope for non-canonical phosphorylation on amino acids such as lysine, arginine and histidine in eukaryotic cells.
Key words: Analytical chemistry, phosphorylation, cell signaling, cool PTMs
Heart Signalling - Chair: Han Kim, Ottawa Heart Institute
Invited Speaker: Dr. Jason Dyck, University of Alberta
Dr. Dyck is the Director of the Cardiovascular Research Group at the University of Alberta. His research team is interested in links between cell signaling and cardiac energy metabolism. Ultimately his work is important for understanding cardiac diseases such as ischemia/reperfusion injury, arrhythmias, and cardiac hypertrophy.
Key words: cardiac biology, resveratrol, glucose, lipid signalling
Rare Diseases - Chair: Dr. Barbara Karten, Dalhousie University
Invited Speaker: Dr. Emily Eden, University College London
Dr. Eden is a senior Research Fellow at the Institute of Ophthalmology, Faculty of Brain Sciences at UCL. She studies the trafficking between the ER and lysosome and how defects in this process can lead to disease. Her group is particularly interested in the transport of lipids, such as cholesterol. Her work is critical for our understanding of rare diseases such as Niemann Pick type-C.
Key words: Niemann Pick type-C (NPC), lysosomal disorders, lipids, ER-lysosome trafficking
Mitochondrial biology - Chair: Dr. Mary-Ellen Harper, University of Ottawa
Invited Speaker: Dr. Rita Horvath, University of Cambridge
Dr. Horvath is a clinician-scientist dedicated to improving the understanding of genetic neurological conditions, with a strong focus on mitochondrial disease and inherited neuropathy. Her laboratory explores specific mitochondrial translation deficiencies as disease mechanisms and works to develop treatments for patients with mitochondrial disease and Charcot-Marie-Tooth disease. She uses several complementary approaches and methodologies, including RNA seq, whole-exome sequencing studies and proteomics.
Keywords: mitochondrial disease, genetics, metabolite transport; metabolomics; mitochondrial respiratory chain
Diabetes - Chair: Dr. Jennifer Estall, IRCM
Invited Speaker: Tim Kieffer, University of British Columbia
The Kieffer lab studies how hormones regulate blood glucose levels and aims to develop gene and cell therapy approaches to re-establish automatic release of insulin within patients with diabetes. Their approaches utilize model cell lines, differentiated stem cells, zebrafish and genetically engineered rodents. He is also working to translate his findings through a number of industry collaborations.
Keywords: stem cells, islets, beta cell regeneration, insulin, hormones, glycemia, encapsulation
Bioinformatics - Chair: Dr. Mathieu Lavallée-Adam, University of Ottawa
Invited Speaker: Dr. Jianguo (Jeff) Xia, McGill
Dr. Xia is an Assistant Professor at McGill University since 2015. His research explores theoretical and practical ways to address the critical challenges in big data analytics arising from biomedical research with the aim of developing highly innovative and useful approaches for metabolomics, transcriptomics, microbiomics and multi-omics integration. Dr. Xia has won several prestigious awards including a Canada Research Chair (Tier 2) and the McGill 2019 Principal’s Prize for Outstanding Emerging Researchers.
Keywords: Big Data, Bioinformatics, Metabolomics, Microbiomics
Cancer metabolism - Chair: Dr. Savraj Grewal, University of Calgary
Invited Speaker: Dr. Heidi Lempradl, Van Andel Research Institute
Dr. Lempradl is an Assistant professor at the Van Andel Research Institute (Grand Rapids Michigan, USA). Her team uses the power of the Drosophila model system to understand how changes in metabolic signalling pathways can impact cell function. Her unique work focuses on the impact of these pathways across generations, from parents to offspring.
Key words: Obesity, diabetes, epigenetics, chromatin, transcription
Metabolic Engineering - Chair: Dr. Vincent Martin (Concordia University)
Invited Speaker: Radhakrishnan Mahadevan, University of Toronto
Dr. Mahadevan is a professor in the Chemical Engineering and Apply Chemistry Department at the University of Toronto. He studies how microorganisms can be used and manipulated to produce new sources of fuels and small molecules. His group is at the forefront of developing new technologies to re-program bacterial cells for new functions. Dr. Mahadevan is the winner of the 2017 Biochemical Engineering Journal Young Investigator Award.
Keywords: Metabolic engineering, chemistry, synthetic biology, bacteria, microbiome, DNA editing
Immunometabolism - Chair: Dr. Erin Mulvihill, Ottawa Heart Institute
Invited Speaker: Dr. Sue Tsai, University of Alberta
Dr. Tsai is a new investigator at the University of Alberta studying immunology and immunometabolism. Her lab is focused on understanding the regulation of the immune response and its connection to metabolism during chronic diseases such as Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D). Using a combination of animal models and vaccination methodologies, her laboratory studies the role of immune and metabolic signaling in disease development and progression.
Keywords: Immunometabolism, immune tolerance, adaptive immunity, diabetes
Lipid Signalling - Chair: Dr. Vanina Zaremberg, University of Calgary
Invited Speaker: Toon de Kroon, Utrecht University
Dr. de Kroon is a professor at Utrecht University in the Netherlands. His research team studies biophysical properties of membranes and how this impacts the function of membrane proteins in the budding yeast. S. cerevisiae model system. His lab uses a combination of genetic and biochemical assays. In application-oriented research, he is also interested in how yeast can be modified to bioengineer hydrophobic molecules with specific properties.
Keywords: Lipids, bioengineering, biophysics, cell membranes, S. cerevisiae
Emerging trends in metabolism - Chair: Dr. Julie St. Pierre, University of Ottawa
Invited Speaker: Dr. Lawrence Kazak, McGill University
Dr. Lawrence Kazak is a new Assistant professor in the Biochemistry Department at McGill. University. His group uses a combination of mouse genetics, mass spectrometry and cell biology techniques to study thermogenesis in adipocytes and other aspects of mitochondrial energetics in cancer cells. He has recently secured funding from CIHR, NSERC and CFI. Recent high-profile publications include a study in Nature Metabolism.
Keywords: adipocytes, mitochondria, creatine, cancer, thermogenesis, cancer biology