PROGRAM

 

THURSDAY, AUGUST 1

 

2:00 - 4:00                  Arrival and check-in

 

3:45 - 4:15                  Refreshments

 

4:15 - 4:30:                 Introduction and Welcome - Joel Levine

 

4:30 - 5:30                  Plenary lecture I - Glial Ensheathment and support of axons

                                   Marc Freeman 

 

5:30 - 7:30                 Symposium 1: Extrinsic/intrinsic regulation of oligodendrocyte development

                                  Chair: Tim Kennedy

 

Intrinsic and extrinsic regulation of myelination and remyelination in the CNS

Charles ffrench-Constant

Modulation of oligodendrocyte development by voltage-gated calcium channels

Pablo Paez

Oligodendrocyte precursor cells become heterogeneous with age: different functional cell states?

Thora Karradottir

Prohibitins in developmental myelination

Emma Wilson (short talk- Feltri lab)          

 

8:00                             Welcome reception and informal BBQ dinner

 

FRIDAY, AUGUST 2

 

7:30 - 8:30                  Breakfast (Eco-Café)

 

8:30 - 10:00                Symposium 2: Immune cells in the normal and diseased CNS; what are they doing there?

                                  Chair: Boris Zalc

 

Lymphatics in the CNS and their role in neurological diseases

Joni Kipnis

Immune mechanisms underlying induction and regulation of remyelination and late-onset auto-immunity           

Stephen Miller 

The impact of T cells on CNS remyelination

Denise Fitzgerald             

 

10:00 - 11:00               Coffee and Poster Session

 

11:00 - 1:00                Symposium 3: Trauma and other diseases of myelin

                                   Chair: Steve Levison

 

Locomotor recovery following contusive spinal cord injury does not require oligodendrocyte remyelination

Wolfram Tetzlaff

Development of the drug to target myelin-derived axon growth inhibitors to repair

Toshihide Yamashita

Oligodendroglia and NG2+ cell vulnerability to oxidative damage at breaches of the blood brain barrier during secondary degeneration following neurotrauma

Melinda Fitzgerald (short talk)

Conditional inactivation of the translation initiation factor eif2b5 gene in oligodendrfocytes induced

a delayed acute neurological distress

Odile Boespflug-Tanguy (short talk)

Divergent oligodendrocyte phenotypes driven by RASopathy mutations associated with MAPK activation level

Alejandro Lopez-Juarez (short talk)

 

1:00 - 2:30                      Lunch and Poster Session

 

2:30 - 3:30                     Plenary lecture 2: Myelin injury and repair in multiple sclerosis

                                     Jack Antel

                                     Chair: Tim Kennedy

 

3:30 - 5:00                     Symposium 4: Trophic dependence and demyelination  

                                      Chair: Terri Wood

 

Are myelin lipids metabolic energy reserves in white matter tracts?

Klaus Nave

Gene edited mouse lines with multiple levels of stable hypomyelination

Alan Peterson

Subtle myelinopathy triggers autoimmune demyelination and progressive atrophy

Andrew Caprariello (short talk-Stys lab)

Mitochondrial localization, dynamics, and bioenergetics are regulated in oligodendrocytes by netrin1

Diana Nakamura (short talk – Kennedy)

 

5:00 - 5:30                      Coffee break

 

5:30 - 7:00                      Young investigator symposium 1:  Molecular control of normal and remyelinating oligodendrocyte and their precursors   

                                       Chair: Haley Titus

 

Oligodendrocytes in the motor cortex from patients with ALS have an RNA trafficking deficit

Samantha Barton

Single-cell transcriptomic analysis aeveals molecular diversity of human oligodendrocyte

precursor cells

Xitis Chamling

The role of mTOR in oligodendrocyte susceptibility to demyelination and efficiency of remyelination

Luipa Khandker

MMP7: an essential player for the removal of remyelination-inhibiting fibronectin aggregates?

Rianne Gorter

Microglial Neuropilin-1 “transactivates” NG2 cell proliferation in the developing and remyelinating brain

Amin Sherafat

The functional role of Transferrin Receptor 1 in peripheral nerve myelination

Jonathan DeGeer

 

8:00                               Dinner

 

SATURDAY, AUGUST 3

 

7:30 - 8:30                     Breakfast (Eco-Café)

 

8:30 - 10:30                  Symposium 5:  New approaches to remyelination

                                     Chair: Wendy Macklin

 

Molecular imaging of the mechanisms driving disability worsening in Multiple Sclerosis

Bruno Stankoff

Sterols and cholesterol synthesis as targets for remyelination

Drew Adams

Hyaluronan fragments regulate myelin gene expression and remyelination through

non-canonical toll-like receptor-4 signaling

Larry Sherman

Motor learning promotes remyelination via oligodendrogenesis, myelin remodelling, and surviving

Ethan Hughes

 

10:30 - 11:00                Coffee break

 

11:00 - 12:30                Symposium 6: Role of other glia in myelin diseases

                                     Chair: Juana Pasquini

The rise and fall of microglia driving central nervous system remyelination

Veronique Miron

Conditional knockout of LKB1 from astrocytes increases inflammatory activation and metabolic dysfuntion: effects on EAE disease

Doug Feinstein

Neuroregenerative and protective functions of Leukemia Inhibitory Factor

Steven Levison

       

12:30 - 5:00                 Lunch and free time

 

5:00 - 5:30                   Coffee break

 

5:30 - 6:30                   Young investigator symposium 2: Oligodendrocyte development and myelin plasticity in aging   

                                    Chair: Haley Titus

 

Transient expression of the glutathione antioxidant system during juvenile oligodendrocyte development

Dylan Verden

Prohibitin 1 preserves axon and myelin integrity in the peripheral nervous system

Gustavo Della-Flores Nunes

Importin 13 is a novel regulator of axon caliber growth and myelination

Janea Bin

Mechanosensing controls CNS myelin sheath elongation

Marie Bechler

 

6:30 - 7:30                   Open panel discussion: MS, where will we be in 5 years, 10 years?

                                    Panel: Carlos Pedraza, Jack Antel

 

8:00                             Dinner

 

9:30                             Bonfire - BYOB

 

SUNDAY, AUGUST  4

 

7:00 - 8:00                   Breakfast

 

8:00 - 9:45                   Symposium 7:  Oligodendrocye function in learning and synaptic transmission, Chair: Akiko Nishiyama

 

Axon-oligodendrocye communication in motor and non-motor learning

Bill Richardson

Effects of oligodendrocyte depolarization on the synaptic function at destination synapses in the hippocampus

Yoshihiko Yamazaki

Role of GABAergic synapses of oligodendrocyte progenitors in regulating axonal myelination and function of parvalbumin interneurons

Maria Cecilla Angulo (short talk)

Environmental enrichment strongly influences oligodendrocyte production and lineage progression in the young adult brain

Madeline Nicholson (short talk- Xiao lab)

 

9:45 – 10:090              Coffee Break

    

10:00 - 12:00              Symposium 8: Oligodendrocyte development and myelination in in adult animals

                                   Chair: Judy Grinspan

 

Outside looking in: exploring external inputs on myelin

Holly Colognato

GPNMB inhibits oligodendrogenesis from neural stem cells in the adult brain

Jayshree Samanta

Investigating the role of fractalkine signalling in oligodendrocyte genesis

in normal and demyelinated brain

Anastassia Voronova

The innate capacity of MS oligodendroglia to produce efficient myelinating oligodendrocytes

Sabah Mozafari (short talk - Anne Baron lab)

New insights on the cellular dynamics that drive production within the oligodendrocyte lineage

David Gonsalvez (short talk)

 

12:15                           Buses depart: To Montreal (The Intercontinental Hotel) and Airport (Pierre Elliott Trudeau airport), a boxed lunch is supplied